Drug Metabolism Databases and High-Throughput Testing During Drug Design and Development.

Medications Development: Drug Discovery, Databases, and Computer-Aided Drug Design

Rational drug design and high-throughput techniques for RNA targets.

RNA molecules are the only known molecules which possess the double property of being depository of genetic information, like DNA, and of displaying catalytic activities, like protein enzymes. RNA molecules intervene in all steps of gene expression and in many other biological activities. Like proteins, RNAs achieve those biological functions by adopting intricate three-dimensional folds and ar...

High throughput drug profiling

High throughput screening has significantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput profiling addresses the issues of compound selectivity and specificity. It combines conventional screening with data mining technologies to g...

Medications Development: Drug Discovery, Databases, and Computer-Aided Drug Design, 134

Application of high throughput technologies to drug substance and drug product development

This presentation describes the application of novel high throughput physical-chemical technologies to the pharmaceutical discovery and development process. The rationale for such platforms is described in light of the changes that have occurred in the biological and chemical processes leading to drug target evaluation and lead identification. Several high throughput platforms are described for...